Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 AlteredExpression LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression LHGDN Pulmonary capillary endothelial metabolic dysfunction: severity in pulmonary arterial hypertension related to connective tissue disease versus idiopathic pulmonary arterial hypertension. 18383374

2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression LHGDN Twenty patients suffering from permanent hypertension were included after a 4 week run-in placebo period in a double-blind, randomized cross-over study comparing the angiotensin-converting enzyme (ACE) inhibitor perindopril with the beta-blocker atenolol during a 4 week treatment period.3. 11903319

2001
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.600 AlteredExpression LHGDN Polymorphism of the ACE Gene in dialysis patients: overexpression of DD genotype in type 2 diabetic end-stage renal failure patients. 16385653

2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.400 AlteredExpression LHGDN Increased expression of monocytic angiotensin-converting enzyme in dialysis patients with cardiovascular disease. 16476718

2006
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.400 AlteredExpression LHGDN Association of coronary artery disease with polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase gene. 19039150

2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.400 AlteredExpression LHGDN The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease. 16116691

2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.400 AlteredExpression LHGDN Our data suggest that genetic variation at the ACE is a genetic factor related with the susceptibility to coronary artery disease in the Mexican Mestizo population. 16764852

2006
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.320 AlteredExpression LHGDN The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism. 15814629

2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 AlteredExpression LHGDN Our findings document that ACE DD genotype represents a susceptibility factor for AAA. 15694792

2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 AlteredExpression LHGDN [Angiotensin-converting enzyme gene and the brachial artery endothelial dysfunction in type 2 diabetes without angiopathy]. 15300633

2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 AlteredExpression LHGDN Angiotensin-converting enzyme genotype and C-reactive protein in patients with COPD. 17400881

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 AlteredExpression LHGDN The distribution of ACE I/D polymorphism and allele frequencies in SLE patients was not significantly different from controls. 17631741

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 AlteredExpression LHGDN Tissue angiotensin-converting enzyme in patients with various clinical forms of psoriasis. 17489742

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.100 AlteredExpression LHGDN Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone. 14671660

2003
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.030 AlteredExpression LHGDN This study investigates whether angiotensin I-converting enzyme (ACE) *A2350G and A-240T gene polymorphisms could be used as markers of susceptibility in endometriosis. 15531592

2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.030 AlteredExpression LHGDN This study investigates whether ACE I/D gene polymorphisms could be used as markers of susceptibility in endometriosis and leiomyoma. 17186537

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0023418
Disease: leukemia
leukemia 		0.030 AlteredExpression LHGDN Circulating and local bone marrow renin-angiotensin system in leukemic hematopoiesis: preliminary evidences. 12186695

2002
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.030 AlteredExpression LHGDN Angiotensin-converting enzyme (CD143) is abundantly expressed by dendritic cells and discriminates human monocyte-derived dendritic cells from acute myeloid leukemia-derived dendritic cells. 14662338

2003
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.020 AlteredExpression LHGDN Angiotensin-converting enzyme-gene polymorphism is associated with collagen I synthesis and QT dispersion in essential hypertension. 12714874

2003
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0023267
Disease: Fibroid Tumor
Fibroid Tumor 		0.020 AlteredExpression LHGDN This study investigates whether ACE I/D gene polymorphisms could be used as markers of susceptibility in endometriosis and leiomyoma. 17186537

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 AlteredExpression LHGDN The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients. 17898867

2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.010 AlteredExpression LHGDN Pulmonary capillary endothelial metabolic dysfunction: severity in pulmonary arterial hypertension related to connective tissue disease versus idiopathic pulmonary arterial hypertension. 18383374

2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker LHGDN No association of the PC-1 Q121 variant and the ACE D/D genotype with DN development was observed. 12147786

2002